Ontology highlight
ABSTRACT:
SUBMITTER: Kim YJ
PROVIDER: S-EPMC5931139 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Acta crystallographica. Section F, Structural biology communications 20180416 Pt 5
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH), a glycolytic enzyme, catalyses the conversion of D-glyceraldehyde 3-phosphate to 1,3-bisphosphoglycerate. While mammalian and yeast GAPDHs are multifunctional proteins that have additional functions beyond those involved in glycolysis, including reactions related to nuclear RNA transport, DNA replication/repair, membrane fusion and cellular apoptosis, Escherichia coli GAPDH (ecGAPDH) has only been reported to function in glycolysis. The S-loop of ...[more]