Ontology highlight
ABSTRACT:
SUBMITTER: Wang S
PROVIDER: S-EPMC5931508 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Wang Shu S Wang Jingya J Kumar Varsha V Karnell Jodi L JL Naiman Brian B Gross Phillip S PS Rahman Saifur S Zerrouki Kamelia K Hanna Richard R Morehouse Christopher C Holoweckyj Nicholas N Liu Hao H Manna Zerai Z Goldbach-Mansky Raphaela R Hasni Sarfaraz S Siegel Richard R Sanjuan Miguel M Streicher Katie K Cancro Michael P MP Kolbeck Roland R Ettinger Rachel R
Nature communications 20180501 1
Although the aetiology of systemic lupus erythematosus (SLE) is unclear, dysregulated B cell responses have been implicated. Here we show that an unusual CD11c<sup>hi</sup>T-bet<sup>+</sup> B cell subset, with a unique expression profile including chemokine receptors consistent with migration to target tissues, is expanded in SLE patients, present in nephrotic kidney, enriched for autoreactive specificities and correlates with defined clinical manifestations. IL-21 can potently induce CD11c<sup> ...[more]