Ontology highlight
ABSTRACT:
SUBMITTER: Sang A
PROVIDER: S-EPMC6162205 | biostudies-other | 2018 Sep
REPOSITORIES: biostudies-other
Sang Allison A Danhorn Thomas T Peterson Jacob N JN Rankin Andrew L AL O'Connor Brian P BP Leach Sonia M SM Torres Raul M RM Pelanda Roberta R
Nature communications 20180928 1
Autoreactive B cells have a major function in autoimmunity. A small subset of B cells expressing two distinct B-cell-antigen-receptors (B<sub>2R</sub> cells) is elevated in many patients with systematic lupus erythematosus (SLE) and in the MRL(/lpr) mouse model of lupus, and is often autoreactive. Here we show, using RNAseq and in vitro and in vivo analyses, signals that are required for promoting B<sub>2R</sub> cell numbers and effector function in autoimmune mice. Compared with conventional B ...[more]