Ontology highlight
ABSTRACT:
SUBMITTER: Hao J
PROVIDER: S-EPMC5932212 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Cancer research 20180206 9
Tumor-associated macrophages (TAM) play a critical role in cancer development and progression. However, the heterogeneity of TAM presents a major challenge to identify clinically relevant markers for protumor TAM. Here, we report that expression of adipocyte/macrophage fatty acid-binding protein (A-FABP) in TAM promotes breast cancer progression. Although upregulation of A-FABP was inversely associated with breast cancer survival, deficiency of A-FABP significantly reduced mammary tumor growth a ...[more]