Ontology highlight
ABSTRACT:
SUBMITTER: Harris ML
PROVIDER: S-EPMC5933715 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
PLoS biology 20180503 5
Melanocyte stem cells (McSCs) and mouse models of hair graying serve as useful systems to uncover mechanisms involved in stem cell self-renewal and the maintenance of regenerating tissues. Interested in assessing genetic variants that influence McSC maintenance, we found previously that heterozygosity for the melanogenesis associated transcription factor, Mitf, exacerbates McSC differentiation and hair graying in mice that are predisposed for this phenotype. Based on transcriptome and molecular ...[more]