Ontology highlight
ABSTRACT:
SUBMITTER: Nakatsukasa H
PROVIDER: S-EPMC5935106 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Nakatsukasa Hiroko H Zhang Dunfang D Maruyama Takashi T Chen Hua H Cui Kairong K Ishikawa Masaki M Deng Lisa L Zanvit Peter P Tu Eric E Jin Wenwen W Abbatiello Brittany B Goldberg Nathan N Chen Qianming Q Sun Lingyun L Zhao Keji K Chen WanJun W
Nature immunology 20150831 10
The molecular mechanisms by which signaling via transforming growth factor-β (TGF-β) and interleukin 4 (IL-4) control the differentiation of CD4(+) IL-9-producing helper T cells (TH9 cells) remain incompletely understood. We found here that the DNA-binding inhibitor Id3 regulated TH9 differentiation, as deletion of Id3 increased IL-9 production from CD4(+) T cells. Mechanistically, TGF-β1 and IL-4 downregulated Id3 expression, and this process required the kinase TAK1. A reduction in Id3 express ...[more]