Ontology highlight
ABSTRACT:
SUBMITTER: Gallagher PS
PROVIDER: S-EPMC5936480 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Gallagher Pamela S PS Larkin Madeline M Thillainadesan Gobi G Dhakshnamoorthy Jothy J Balachandran Vanivilasini V Xiao Hua H Wellman Christopher C Chatterjee Raghunath R Wheeler David D Grewal Shiv I S SIS
Nature structural & molecular biology 20180423 5
Iron metabolism is critical for sustaining life and maintaining human health. Here, we find that iron homeostasis is linked to facultative heterochromatin assembly and regulation of gene expression during adaptive genome control. We show that the fission yeast Clr4/Suv39h histone methyltransferase is part of a rheostat-like mechanism in which transcriptional upregulation of mRNAs in response to environmental change provides feedback to prevent their uncontrolled expression through heterochromati ...[more]