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Decarboxylative Annulation of ?-Amino Acids with ?-Ketoaldehydes.

ABSTRACT: Indolizidine and quinolizidine derivatives are readily assembled from l-proline or (±)-pipecolic acid and ?-ketoaldehydes via a decarboxylative annulation process. These reactions are promoted by acetic acid and involve azomethine ylides as reactive intermediates.

SUBMITTER: Paul A

PROVIDER: S-EPMC5937137 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature

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Decarboxylative Annulation of α-Amino Acids with β-Ketoaldehydes.

Paul Anirudra A Thimmegowda N R NR Galani Cruz Thiago T Seidel Daniel D

Organic letters 20180112 3

Indolizidine and quinolizidine derivatives are readily assembled from l-proline or (±)-pipecolic acid and β-ketoaldehydes via a decarboxylative annulation process. These reactions are promoted by acetic acid and involve azomethine ylides as reactive intermediates. ...[more]

PMID: 29328663

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