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Decarboxylative Polyfluoroarylation of Alkylcarboxylic Acids.

ABSTRACT: Polyfluoroarenes are useful building blocks in several areas such as drug discovery, materials, and crop protection. Herein, we report the first polyfluoroarylation of aliphatic carboxylic acids via photoredox decarboxylation. The method proceeds with broad substrate scope and high functional group tolerance. Moreover, small complex molecules such as natural products and drugs can be modified by late-stage modification.

SUBMITTER: Sun X

PROVIDER: S-EPMC8252513 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature

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Decarboxylative Polyfluoroarylation of Alkylcarboxylic Acids.

Sun Xiang X Ritter Tobias T

Angewandte Chemie (International ed. in English) 20210330 19

Polyfluoroarenes are useful building blocks in several areas such as drug discovery, materials, and crop protection. Herein, we report the first polyfluoroarylation of aliphatic carboxylic acids via photoredox decarboxylation. The method proceeds with broad substrate scope and high functional group tolerance. Moreover, small complex molecules such as natural products and drugs can be modified by late-stage modification. ...[more]

PMID: 33481305

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