Unknown

Dataset Information

0

Improving the biopharmaceutical attributes of mangiferin using vitamin E-TPGS co-loaded self-assembled phosholipidic nano-mixed micellar systems.


ABSTRACT: The current research work encompasses the development, characterization, and evaluation of self-assembled phospholipidic nano-mixed miceller system (SPNMS) of a poorly soluble BCS Class IV xanthone bioactive, mangiferin (Mgf) functionalized with co-delivery of vitamin E TPGS. Systematic optimization using I-optimal design yielded self-assembled phospholipidic nano-micelles with a particle size of ?80% of drug release in 15 min. The cytotoxicity and cellular uptake studies performed using MCF-7 and MDA-MB-231 cell lines demonstrated greater kill and faster cellular uptake. The ex vivo intestinal permeability revealed higher lymphatic uptake, while in situ perfusion and in vivo pharmacokinetic studies indicated nearly 6.6- and 3.0-folds augmentation in permeability and bioavailability of Mgf. In a nutshell, vitamin E functionalized SPNMS of Mgf improved the biopharmaceutical performance of Mgf in rats for enhanced anticancer potency.

SUBMITTER: Khurana RK 

PROVIDER: S-EPMC5937873 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature

altmetric image

Publications

Improving the biopharmaceutical attributes of mangiferin using vitamin E-TPGS co-loaded self-assembled phosholipidic nano-mixed micellar systems.

Khurana Rajneet Kaur RK   Gaspar Balan Louis BL   Welsby Gail G   Katare O P OP   Singh Kamalinder K KK   Singh Bhupinder B  

Drug delivery and translational research 20180601 3


The current research work encompasses the development, characterization, and evaluation of self-assembled phospholipidic nano-mixed miceller system (SPNMS) of a poorly soluble BCS Class IV xanthone bioactive, mangiferin (Mgf) functionalized with co-delivery of vitamin E TPGS. Systematic optimization using I-optimal design yielded self-assembled phospholipidic nano-micelles with a particle size of < 60 nm and > 80% of drug release in 15 min. The cytotoxicity and cellular uptake studies performed  ...[more]

Similar Datasets

| S-EPMC5739610 | biostudies-literature
| S-EPMC11314731 | biostudies-literature
| S-EPMC7401050 | biostudies-literature
| S-EPMC5428804 | biostudies-literature
| S-EPMC8465222 | biostudies-literature
| S-EPMC6241863 | biostudies-other
| S-EPMC10879835 | biostudies-literature
| S-EPMC5736557 | biostudies-literature
| S-EPMC5580261 | biostudies-literature
| S-EPMC9570305 | biostudies-literature