Ontology highlight
ABSTRACT:
SUBMITTER: Basahih TS
PROVIDER: S-EPMC7401050 | biostudies-literature | 2020 Jul-Sep
REPOSITORIES: biostudies-literature
Basahih Tahani S TS Alamoudi Abdullah A AA El-Say Khalid M KM Alhakamy Nabil A NA Ahmed Osama A A OAA
Dose-response : a publication of International Hormesis Society 20200731 3
Glimepiride (GMD) is a hypoglycemic agent that has variation in bioavailability for its unexpected absorption. Glimepiride was formulated in a buccal film loaded with a nanobased formulation to enhance its absorption via buccal mucosa. Nanostructured lipid carriers (NLCs) and d-α-tocopherol polyethylene glycol 1000 succinate-based micelles enhance GMD solubility and improve its permeation through the buccal mucosa. The formulation variables were optimized using a Box-Behnken design. These factor ...[more]