Ontology highlight
ABSTRACT:
SUBMITTER: Vion AC
PROVIDER: S-EPMC5940299 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Vion Anne-Clémence AC Alt Silvanus S Klaus-Bergmann Alexandra A Szymborska Anna A Zheng Tuyu T Perovic Tijana T Hammoutene Adel A Oliveira Marta Bastos MB Bartels-Klein Eireen E Hollfinger Irene I Rautou Pierre-Emmanuel PE Bernabeu Miguel O MO Gerhardt Holger H
The Journal of cell biology 20180302 5
Blood flow shapes vascular networks by orchestrating endothelial cell behavior and function. How endothelial cells read and interpret flow-derived signals is poorly understood. Here, we show that endothelial cells in the developing mouse retina form and use luminal primary cilia to stabilize vessel connections selectively in parts of the remodeling vascular plexus experiencing low and intermediate shear stress. Inducible genetic deletion of the essential cilia component intraflagellar transport ...[more]