Ontology highlight
ABSTRACT:
SUBMITTER: de Graaf KL
PROVIDER: S-EPMC5944576 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
de Graaf Kathy L KL Lapeyre Geneviève G Guilhot Florence F Ferlin Walter W Curbishley Stuart M SM Carbone Marco M Richardson Paul P Moreea Sulleman S McCune C Anne CA Ryder Stephen D SD Chapman Roger W RW Floreani Annarosa A Jones David E DE de Min Cristina C Adams David H DH Invernizzi Pietro P
Hepatology communications 20180323 5
NI-0801 is a fully human monoclonal antibody against chemokine (C-X-C motif) ligand 10 (CXCL10), which is involved in the recruitment of inflammatory T cells into the liver. The safety and efficacy of NI-0801 was assessed in patients with primary biliary cholangitis. In this open-label phase 2a study, patients with primary biliary cholangitis with an inadequate response to ursodeoxycholic acid received six consecutive intravenous administrations of NI-0801 (10 mg/kg) every 2 weeks. Patients were ...[more]