NNOS-CAPON interaction mediates amyloid-?-induced neurotoxicity, especially in the early stages.
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ABSTRACT:
SUBMITTER: Zhang Y
PROVIDER: S-EPMC5946066 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Publications
nNOS-CAPON interaction mediates amyloid-β-induced neurotoxicity, especially in the early stages.
Zhang Yu Y Zhu Zhu Z Liang Hai-Ying HY Zhang Lei L Zhou Qi-Gang QG Ni Huan-Yu HY Luo Chun-Xia CX Zhu Dong-Ya DY
Aging cell 20180325 3
In neurons, increased protein-protein interactions between neuronal nitric oxide synthase (nNOS) and its carboxy-terminal PDZ ligand (CAPON) contribute to excitotoxicity and abnormal dendritic spine development, both of which are involved in the development of Alzheimer's disease. In models of Alzheimer's disease, increased nNOS-CAPON interaction was detected after treatment with amyloid-β in vitro, and a similar change was found in the hippocampus of APP/PS1 mice (a transgenic mouse model of Al ...[more]
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