Ontology highlight
ABSTRACT:
SUBMITTER: Abboud MI
PROVIDER: S-EPMC5947706 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Abboud Martine I MI Kosmopoulou Magda M Krismanich Anthony P AP Johnson Jarrod W JW Hinchliffe Philip P Brem Jürgen J Claridge Timothy D W TDW Spencer James J Schofield Christopher J CJ Dmitrienko Gary I GI
Chemistry (Weinheim an der Bergstrasse, Germany) 20180117 22
The most important resistance mechanism to β-lactam antibiotics involves hydrolysis by two β-lactamase categories: the nucleophilic serine and the metallo-β-lactamases (SBLs and MBLs, respectively). Cyclobutanones are hydrolytically stable β-lactam analogues with potential to inhibit both SBLs and MBLs. We describe solution and crystallographic studies on the interaction of a cyclobutanone penem analogue with the clinically important MBL SPM-1. NMR experiments using <sup>19</sup> F-labeled SPM-1 ...[more]