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Cobalt Catalysis for Enantioselective Cyclobutanone Construction.

ABSTRACT: Over the past 40 years, intramolecular hydroacylation has favored five-membered rings, in preference to four membered rings. Herein, we report a catalyst derived from earth-abundant cobalt that enables preparation of cyclobutanones, with excellent regio-, diastereo-, and enantiocontrol, under mild conditions (2 mol % catalyst loading and as low as 50 °C).

SUBMITTER: Kim DK

PROVIDER: S-EPMC6824591 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature

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Cobalt Catalysis for Enantioselective Cyclobutanone Construction.

Kim Daniel K DK Riedel Jan J Kim Raphael S RS Dong Vy M VM

Journal of the American Chemical Society 20170713 30

Over the past 40 years, intramolecular hydroacylation has favored five-membered rings, in preference to four membered rings. Herein, we report a catalyst derived from earth-abundant cobalt that enables preparation of cyclobutanones, with excellent regio-, diastereo-, and enantiocontrol, under mild conditions (2 mol % catalyst loading and as low as 50 °C). ...[more]

PMID: 28704053

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