Ontology highlight
ABSTRACT:
SUBMITTER: Pallela VR
PROVIDER: S-EPMC5949069 | biostudies-literature | 2013 Mar
REPOSITORIES: biostudies-literature
Pallela Venkat R VR Mallireddigari Muralidhar R MR Cosenza Stephen C SC Akula Balaiah B Subbaiah D R C Venkata DR Reddy E Premkumar EP Reddy M V Ramana MV
Organic & biomolecular chemistry 20130206 12
A stereoselective and efficient method for free radical addition of benzyl thiol to aryl acetylene in the presence of Et3B-hexane has been developed for the synthesis of (Z) and (E)-styryl benzyl sulfides where base catalyzed hydrothiolations have failed. The scope of this reaction was successfully extended for the synthesis of (E)-ON 01910·Na, a phase III clinical stage anti-cancer agent and its inactive geometrical isomer (Z)-ON 01910·Na. It is interesting to note that all the E-isomers synthe ...[more]