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A review of connectivity map and computational approaches in pharmacogenomics.

ABSTRACT: Large-scale perturbation databases, such as Connectivity Map (CMap) or Library of Integrated Network-based Cellular Signatures (LINCS), provide enormous opportunities for computational pharmacogenomics and drug design. A reason for this is that in contrast to classical pharmacology focusing at one target at a time, the transcriptomics profiles provided by CMap and LINCS open the door for systems biology approaches on the pathway and network level. In this article, we provide a review of recent developments in computational pharmacogenomics with respect to CMap and LINCS and related applications.

SUBMITTER: Musa A

PROVIDER: S-EPMC5952941 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature

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A review of connectivity map and computational approaches in pharmacogenomics.

Musa Aliyu A Ghoraie Laleh Soltan LS Zhang Shu-Dong SD Glazko Galina G Yli-Harja Olli O Dehmer Matthias M Haibe-Kains Benjamin B Emmert-Streib Frank F

Briefings in bioinformatics 20180501 3

Large-scale perturbation databases, such as Connectivity Map (CMap) or Library of Integrated Network-based Cellular Signatures (LINCS), provide enormous opportunities for computational pharmacogenomics and drug design. A reason for this is that in contrast to classical pharmacology focusing at one target at a time, the transcriptomics profiles provided by CMap and LINCS open the door for systems biology approaches on the pathway and network level. In this article, we provide a review of recent d ...[more]

PMID: 28069634

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