Ontology highlight
ABSTRACT:
SUBMITTER: Zhong J
PROVIDER: S-EPMC5955621 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Zhong Jianghong J Scholz Tatjana T Yau Anthony C Y ACY Guerard Simon S Hüffmeier Ulrike U Burkhardt Harald H Holmdahl Rikard R
Science advances 20180516 5
Previous identification of the inducible nitric oxide synthase (NOS2) gene as a risk allele for psoriasis (Ps) and psoriatic arthritis (PsA) suggests a possible pathogenic role of nitric oxide (NO). Using a mouse model of mannan-induced Ps and PsA (MIP), where macrophages play a regulatory role by releasing reactive oxygen species (ROS), we found that NO was detectable before disease onset in mice, independent of a functional nicotinamide adenine dinucleotide phosphate oxidase 2 complex. MIP was ...[more]