Ontology highlight
ABSTRACT:
SUBMITTER: Reynolds KA
PROVIDER: S-EPMC5960985 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Reynolds Kirk A KA Luhavaya Hanna H Li Jie J Dahesh Samira S Nizet Victor V Yamanaka Kazuya K Moore Bradley S BS
The Journal of antibiotics 20171129 2
In the ongoing effort to unlock the chemical potential of marine bacteria, genetic engineering of biosynthetic gene clusters (BGCs) is increasingly used to awake or improve expression of biosynthetic genes that may lead to discovery of novel bioactive natural products. Previously, we reported the successful capture, engineering and heterologous expression of an orphan BGC from the marine actinomycete Saccharomonospora sp. CNQ-490, which resulted in the isolation of the novel lipopeptide antibiot ...[more]