Ontology highlight
ABSTRACT:
SUBMITTER: Muller C
PROVIDER: S-EPMC1803135 | biostudies-literature | 2007 Mar
REPOSITORIES: biostudies-literature
Müller C C Nolden S S Gebhardt P P Heinzelmann E E Lange C C Puk O O Welzel K K Wohlleben W W Schwartz D D
Antimicrobial agents and chemotherapy 20070112 3
Actinoplanes friuliensis produces the lipopeptide antibiotic friulimicin, which is a cyclic peptide with one exocyclic amino acid linked to a branched-chain fatty acid acyl residue. The structural relationship to daptomycin and the excellent antibacterial performance of friulimicin make the antibiotic an attractive drug candidate. The complete friulimicin biosynthetic gene cluster of 24 open reading frames from A. friuliensis was sequenced and analyzed. In addition to genes for regulation, self- ...[more]