Ontology highlight
ABSTRACT:
SUBMITTER: Eskilsson E
PROVIDER: S-EPMC5961011 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Neuro-oncology 20180501 6
Patients with glioblastoma (GBM) have a universally poor prognosis and are in urgent need of effective treatment strategies. Recent advances in sequencing techniques unraveled the complete genomic landscape of GBMs and revealed profound heterogeneity of individual tumors even at the single cell level. Genomic profiling has detected epidermal growth factor receptor (EGFR) gene alterations in more than half of GBMs. Major genetic events include amplification and mutation of EGFR. Yet, treatment st ...[more]