Ontology highlight
ABSTRACT:
SUBMITTER: Race NJ
PROVIDER: S-EPMC5963672 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Chemical science 20151201 2
Pd-catalyzed cyclizations of oxime esters with pendant alkenes are subject to an unusual ligand controlled mechanistic divergence. Pd-systems modified with electron deficient phosphines (<i>e.g.</i> P(3,5-(CF<sub>3</sub>)<sub>2</sub>C<sub>6</sub>H<sub>3</sub>)<sub>3</sub>) promote efficient aza-Heck cyclization, wherein C-N bond formation occurs <i>via</i> alkene imino-palladation. Conversely, electron rich ligands, such as P(<i>t</i>-Bu)<sub>3</sub>, cause deviation to a SET pathway and, in the ...[more]