Ontology highlight
ABSTRACT:
SUBMITTER: Scheib U
PROVIDER: S-EPMC5967339 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Scheib Ulrike U Broser Matthias M Constantin Oana M OM Yang Shang S Gao Shiqiang S Mukherjee Shatanik S Stehfest Katja K Nagel Georg G Gee Christine E CE Hegemann Peter P
Nature communications 20180524 1
The cyclic nucleotides cAMP and cGMP are important second messengers that orchestrate fundamental cellular responses. Here, we present the characterization of the rhodopsin-guanylyl cyclase from Catenaria anguillulae (CaRhGC), which produces cGMP in response to green light with a light to dark activity ratio >1000. After light excitation the putative signaling state forms with τ = 31 ms and decays with τ = 570 ms. Mutations (up to 6) within the nucleotide binding site generate rhodopsin-adenylyl ...[more]