Ontology highlight
ABSTRACT:
SUBMITTER: Fan C
PROVIDER: S-EPMC5967863 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Fan Chen C Choi Wooyoung W Sun Weinan W Du Juan J Lü Wei W
eLife 20180504
The TRPC channels are crucially involved in store-operated calcium entry and calcium homeostasis, and they are implicated in human diseases such as neurodegenerative disease, cardiac hypertrophy, and spinocerebellar ataxia. We present a structure of the full-length human TRPC3, a lipid-gated TRPC member, in a lipid-occupied, closed state at 3.3 Angstrom. TRPC3 has four elbow-like membrane reentrant helices prior to the first transmembrane helix. The TRP helix is perpendicular to, and thus diseng ...[more]