Ontology highlight
ABSTRACT:
SUBMITTER: Zhang MS
PROVIDER: S-EPMC5969542 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Cell cycle (Georgetown, Tex.) 20180405 6
RCC1 associates to chromatin dynamically within mitosis and catalyzes Ran-GTP production. Exogenous RCC1 disrupts kinetochore structure in Xenopus egg extracts (XEEs), but the molecular basis of this disruption remains unknown. We have investigated this question, utilizing replicated chromosomes that possess paired sister kinetochores. We find that exogenous RCC1 evicts a specific subset of inner KT proteins including Shugoshin-1 (Sgo1) and the chromosome passenger complex (CPC). We generated RC ...[more]