Ontology highlight
ABSTRACT:
SUBMITTER: Gsaller F
PROVIDER: S-EPMC5971587 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Gsaller Fabio F Furukawa Takanori T Carr Paul D PD Rash Bharat B Jöchl Christoph C Bertuzzi Margherita M Bignell Elaine M EM Bromley Michael J MJ
Antimicrobial agents and chemotherapy 20180525 6
The antifungal drug 5-flucytosine (5FC), a derivative of the nucleobase cytosine, is licensed for the treatment of fungal diseases; however, it is rarely used as a monotherapeutic to treat <i>Aspergillus</i> infection. Despite being potent against other fungal pathogens, 5FC has limited activity against <i>Aspergillus fumigatus</i> when standard <i>in vitro</i> assays are used to determine susceptibility. However, in modified <i>in vitro</i> assays where the pH is set to pH 5, the activity of 5F ...[more]