Ontology highlight
ABSTRACT:
SUBMITTER: Liu X
PROVIDER: S-EPMC5977995 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Liu Xiao X Ishizuka Takumi T Bao Hong-Liang HL Wada Kei K Takeda Yuma Y Iida Keisuke K Nagasawa Kazuo K Yang Danzhou D Xu Yan Y
Journal of the American Chemical Society 20170524 22
Telomeric repeat-containing RNA is a new noncoding RNA molecule that performs various biofunctions. Heterogeneous nuclear ribonucleoprotein (hnRNP) A1 is an RNA-binding protein involved in the telomere maintenance machinery. To date, little is known about how hnRNPA1 binds to telomeric RNA. In this study, we investigated the binding affinity and recognition mechanism of telomere RNA with the RNA recognition motif of hnRNPA1. Using the photochemical cross-linking method, we showed that the telome ...[more]