Loss of POMC-mediated antinociception contributes to painful diabetic neuropathy.
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ABSTRACT:
SUBMITTER: Deshpande D
PROVIDER: S-EPMC7814083 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
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Loss of POMC-mediated antinociception contributes to painful diabetic neuropathy.
Deshpande Divija D Agarwal Nitin N Fleming Thomas T Gaveriaux-Ruff Claire C Klose Christoph S N CSN Tappe-Theodor Anke A Kuner Rohini R Nawroth Peter P
Nature communications 20210118 1
Painful neuropathy is a frequent complication in diabetes. Proopiomelanocortin (POMC) is an endogenous opioid precursor peptide, which plays a protective role against pain. Here, we report dysfunctional POMC-mediated antinociception in sensory neurons in diabetes. In streptozotocin-induced diabetic mice the Pomc promoter is repressed due to increased binding of NF-kB p50 subunit, leading to a loss in basal POMC level in peripheral nerves. Decreased POMC levels are also observed in peripheral ner ...[more]
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