Ontology highlight
ABSTRACT:
SUBMITTER: Xiang W
PROVIDER: S-EPMC5987722 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Xiang Wanqing W Roberti M Julia MJ Hériché Jean-Karim JK Huet Sébastien S Alexander Stephanie S Ellenberg Jan J
The Journal of cell biology 20180323 6
Chromosome organization in higher eukaryotes controls gene expression, DNA replication, and DNA repair. Genome mapping has revealed the functional units of chromatin at the submegabase scale as self-interacting regions called topologically associating domains (TADs) and showed they correspond to replication domains (RDs). A quantitative structural and dynamic description of RD behavior in the nucleus is, however, missing because visualization of dynamic subdiffraction-sized RDs remains challengi ...[more]