Dynamics of sister chromatid resolution during cell cycle progression.
Ontology highlight
ABSTRACT:
SUBMITTER: Stanyte R
PROVIDER: S-EPMC5987726 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Publications
Dynamics of sister chromatid resolution during cell cycle progression.
Stanyte Rugile R Nuebler Johannes J Blaukopf Claudia C Hoefler Rudolf R Stocsits Roman R Peters Jan-Michael JM Gerlich Daniel W DW
The Journal of cell biology 20180425 6
Faithful genome transmission in dividing cells requires that the two copies of each chromosome's DNA package into separate but physically linked sister chromatids. The linkage between sister chromatids is mediated by cohesin, yet where sister chromatids are linked and how they resolve during cell cycle progression has remained unclear. In this study, we investigated sister chromatid organization in live human cells using dCas9-mEGFP labeling of endogenous genomic loci. We detected substantial si ...[more]
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