FOXQ1 controls the induced differentiation of melanocytic cells.
Ontology highlight
ABSTRACT:
SUBMITTER: Bagati A
PROVIDER: S-EPMC5988681 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Publications
FOXQ1 controls the induced differentiation of melanocytic cells.
Bagati Archis A Bianchi-Smiraglia Anna A Moparthy Sudha S Kolesnikova Kateryna K Fink Emily E EE Kolesnikova Masha M Roll Matthew V MV Jowdy Peter P Wolff David W DW Polechetti Anthony A Yun Dong Hyun DH Lipchick Brittany C BC Paul Leslie M LM Wrazen Brian B Moparthy Kalyana K Mudambi Shaila S Morozevich Galina E GE Georgieva Sofia G SG Wang Jianmin J Shafirstein Gal G Liu Song S Kandel Eugene S ES Berman Albert E AE Box Neil F NF Paragh Gyorgy G Nikiforov Mikhail A MA
Cell death and differentiation 20180220 6
Oncogenic transcription factor FOXQ1 has been implicated in promotion of multiple transformed phenotypes in carcinoma cells. Recently, we have characterized FOXQ1 as a melanoma tumor suppressor that acts via repression of N-cadherin gene, and invasion and metastasis. Here we report that FOXQ1 induces differentiation in normal and transformed melanocytic cells at least partially via direct transcriptional activation of MITF gene, melanocytic lineage-specific regulator of differentiation. Importan ...[more]
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