Ontology highlight
ABSTRACT:
SUBMITTER: Kabbert J
PROVIDER: S-EPMC7526496 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
The Journal of experimental medicine 20201101 11
The gut is home to the body's largest population of plasma cells. In healthy individuals, IgA is the dominating isotype, whereas patients with inflammatory bowel disease also produce high concentrations of IgG. In the gut lumen, secretory IgA binds pathogens and toxins but also the microbiota. However, the antigen specificity of IgA and IgG for the microbiota and underlying mechanisms of antibody binding to bacteria are largely unknown. Here we show that microbiota binding is a defining property ...[more]