Ontology highlight
ABSTRACT:
SUBMITTER: Mordhorst BR
PROVIDER: S-EPMC6603033 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Mordhorst Bethany R BR Kerns Karl C KC Schauflinger Martin M Zigo Michal M Murphy Stephanie L SL Ross Renee M RM Wells Kevin D KD Green Jonathan A JA Sutovsky Peter P Prather Randall S RS
Scientific reports 20190701 1
A metabolic phenomenon known as the Warburg effect has been characterized in certain cancerous cells, embryonic stem cells, and other rapidly proliferative cell types. Previously, our attempts to induce a Warburg-like state pharmaceutically via CPI-613 and PS48 treatment did augment metabolite production and gene expression; however, this treatment demonstrated a Reverse Warburg effect phenotype observed in cancer-associated stroma. In the current study, we inquired whether the mitochondria were ...[more]