Ontology highlight
ABSTRACT:
SUBMITTER: Medelnik JP
PROVIDER: S-EPMC5993681 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Medelnik Jan-Philip JP Roensch Kathleen K Okawa Satoshi S Del Sol Antonio A Chara Osvaldo O Mchedlishvili Levan L Tanaka Elly M EM
Stem cell reports 20180517 6
In the developing nervous system, neural stem cells are polarized and maintain an apical domain facing a central lumen. The presence of apical membrane is thought to have a profound influence on maintaining the stem cell state. With the onset of neurogenesis, cells lose their polarization, and the concomitant loss of the apical domain coincides with a loss of the stem cell identity. Little is known about the molecular signals controlling apical membrane size. Here, we use two neuroepithelial cel ...[more]