Ontology highlight
ABSTRACT:
SUBMITTER: El Waly B
PROVIDER: S-EPMC5995160 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
El Waly Bilal B Cayre Myriam M Durbec Pascale P
Stem cell reports 20180329 5
Demyelination is frequently observed in a variety of CNS insults and neurodegenerative diseases. In rodents, adult neural stem cells can generate oligodendrocytes and participate to myelin repair. However, these cells mainly produce migratory neuroblasts that differentiate in the olfactory bulb. Here, we show that, in the demyelination context, a small subset of these neuroblasts can spontaneously convert into myelinating oligodendrocytes. Furthermore, we demonstrate that the contribution of neu ...[more]