Marijuana use differentially affects cannabinoid receptor expression in early gestational human endometrium and placenta.
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ABSTRACT:
SUBMITTER: Neradugomma NK
PROVIDER: S-EPMC5995327 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Publications
Marijuana use differentially affects cannabinoid receptor expression in early gestational human endometrium and placenta.
Neradugomma Naveen K NK Drafton Kaitlyn K O'Day Diana R DR Liao Michael Z MZ Han Lyrialle W LW Glass Ian A IA Mao Qingcheng Q
Placenta 20180509
Marijuana is one of the most abused drugs among pregnant women leading to maternal and fetal abnormalities. Cannabinoids are the active ingredients of marijuana, which interact with cannabinoid receptors such as CNR1 and CNR2 to activate cellular signaling pathways. Human endometrium and placenta are known to express CNR1 and CNR2 and can respond to cannabinoid signaling. In this study, we show that marijuana use significantly increases mRNA or protein expression of CNR1 and CNR2 in human endome ...[more]
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