Ontology highlight
ABSTRACT:
SUBMITTER: Fung K
PROVIDER: S-EPMC7287814 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Fung Kimberly K Vivier Delphine D Keinänen Outi O Sarbisheh Elaheh Khozeimeh EK Price Eric W EW Zeglis Brian M BM
Molecules (Basel, Switzerland) 20200515 10
High expression levels of the tumor-associated antigen MUC1 have been correlated with tumor aggressiveness, poor response to therapy, and poor survival in several tumor types, including breast, pancreatic, and epithelial ovarian cancer. Herein, we report the synthesis, characterization, and in vivo evaluation of a novel radioimmunoconjugate for the immuno-positron emission tomography (immunoPET) imaging of MUC1 expression based on the AR20.5 antibody. To this end, we modified AR20.5 with the che ...[more]