Dataset Information

Study of the association of 17 lipid-related gene polymorphisms with coronary heart disease.

ABSTRACT: OBJECTIVE:Blood lipids are well-known risk factors for coronary heart disease (CHD). The aim of this study was to explore the association between 17 lipid-related gene polymorphisms and CHD. METHODS:The current study examined with 784 CHD cases and 739 non-CHD controls. Genotyping was performed on the MassARRAY iPLEX® assay platform. RESULTS:Our analyses revealed a significant association of APOE rs7259620 with CHD (genotype: ?2=6.353, df=2, p=0.042; allele: ?2=5.05, df=1, p=0.025; recessive model: ?2=5.57, df=1, p=0.018). A further gender-based subgroup analysis revealed significant associations of APOE rs7259620 and PPAP2B rs72664392 with CHD in males (genotype: ?2=8.379, df=2, p=0.015; allele: ?2=5.190, df=1, p=0.023; recessive model: ?2=19.3, df=1, p<0.0001) and females (genotype: ?2=9.878, df=2, p=0.007), respectively. Subsequent breakdown analysis by age showed that CETP rs4783961, MLXIPL rs35493868, and PON2 rs12704796 were significantly associated with CHD among individuals younger than 55 years of age (CETP rs4783961: ?2=8.966, df=1, p=0.011 by genotype; MLXIPL rs35493868: ?2=4.87, df=1, p=0.027 by allele; ?2=4.88, df=1, p=0.027 by dominant model; PON2 rs12704796: ?2=6.511, df=2, p=0.039 by genotype; ?2=6.210, df=1, p=0.013 by allele; ?2=5.03, df=1, p=0.025 by dominant model). Significant allelic association was observed between LEPR rs656451 and CHD among individuals older than 65 years of age (?2=4.410, df=1, p=0.036). CONCLUSION:Our study revealed significant associations of APOE, PPAP2B, CETP, MLXIPL, PON2, and LEPR gene polymorphisms with CHD among the Han Chinese.

SUBMITTER: Wu N

PROVIDER: S-EPMC5998860 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature

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Study of the association of 17 lipid-related gene polymorphisms with coronary heart disease.

Wu Nan N Liu Guili G Huang Yi Y Liao Qi Q Han Liyuan L Ye Huandan H Duan Shiwei S Chen Xiaomin X

Anatolian journal of cardiology 20180601 6

<h4>Objective</h4>Blood lipids are well-known risk factors for coronary heart disease (CHD). The aim of this study was to explore the association between 17 lipid-related gene polymorphisms and CHD.<h4>Methods</h4>The current study examined with 784 CHD cases and 739 non-CHD controls. Genotyping was performed on the MassARRAY iPLEX® assay platform.<h4>Results</h4>Our analyses revealed a significant association of APOE rs7259620 with CHD (genotype: χ2=6.353, df=2, p=0.042; allele: χ2=5.05, df=1, ...[more]

PMID: 29848931

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Project description:Polymorphisms in the apolipoprotein C-III (APOC3) gene have been reported to be associated with coronary heart disease (CHD), but the data so far have been conflicting. To derive a more precise estimation of these associations, we performed a meta-analysis to investigate the three main polymorphisms (SstI, T-455C, C-482T) of APOC3 in all published studies. Databases including PubMed, Web of Science, Wanfang, SinoMed and CNKI were systematically searched. The association was assessed using odds ratios (ORs) with 95% confidence intervals (CIs). The statistical analysis was performed using Review Manager 5.3.3 and Stata 12.0. A total of 31 studies have been identified. The pooled odds ratio (OR) for the association between the APOC3 gene polymorphisms and CHD and its corresponding 95% confidence interval (95% CI) were evaluated by random or fixed effect models. A statistical association between APOC3 SstI polymorphism and CHD susceptibility was observed under an allelic contrast model (P= 0.003, OR = 1.14, 95% CI = 1.05-1.24), dominant genetic model (P= 0.01, OR = 1.14, 95% CI = 1.03-1.26), and recessive genetic model (P= 0.02, OR = 1.35, 95% CI = 1.06-1.71), respectively. A significant association between the APOC3 T-455C polymorphism and CHD was also detected under an allelic contrast (P < 0.0001, OR = 1.19, 95% CI = 1.10-1.29), dominant genetic model (P= 0.0003, OR = 1.24, 95% CI = 1.11-1.39) and recessive genetic model (P= 0.04, OR = 1.30, 95% CI = 1.01-1.67). No significant association between the APOC3 C-482T polymorphism and CHD was found under an allelic model (P= 0.94, OR = 1.00, 95% CI = 0.93-1.08), dominant genetic model (P= 0.20, OR = 1.07, 95% CI = 0.97-1.18) or recessive genetic model (P= 0.13, OR = 0.90, 95% CI = 0.79-1.03). This meta-analysis revealed that the APOC3 SstI and T-455C polymorphisms significantly increase CHD susceptibility. No significant association was observed between the APOC3 C-482T polymorphism and CHD susceptibility.

Dataset Information

Study of the association of 17 lipid-related gene polymorphisms with coronary heart disease.

Publications

Study of the association of 17 lipid-related gene polymorphisms with coronary heart disease.

Similar Datasets

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