Ontology highlight
ABSTRACT:
SUBMITTER: Polesskaya O
PROVIDER: S-EPMC5998900 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
BMC neuroscience 20180419 Suppl 1
Optogenetics has become widely recognized for its success in real-time control of brain neurons by utilizing non-mammalian photosensitive proteins to open or close membrane channels. Here we review a less well known type of optogenetic constructs that employs photosensitive proteins to transduce the signal to regulate gene transcription, and its possible use in medicine. One of the problems with existing gene therapies is that they could remain active indefinitely while not allowing regulated tr ...[more]