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Data on investigation of hypoglycemic, anti-cholesteremic, in vivo antioxidant and pancreatic beta cell protective effect of Putranjiva roxburghii Wall bark in streptozotocin-induced diabetic rats.

ABSTRACT: The data existing in this article are associated to the antidiabetic activity of ethyl acetate extract of Putranjiva roxburghii Wall barks (EAPR) in streptozotocin (STZ) induced diabetic rats at a dose of 250 & 500?mg/kg by oral route for 21 days. The phytochemical screening of the extract was carried out by gas chromatography and mass spectrometry. Diabetes was induced by streptozotocin (50?mg/kg; i.p), EAPR (250 & 500?mg/kg; b.wt) and standard Insulin (6?IU/animal; subcutaneous; o.i.d) were administered to the diabetic rats. Body weight and blood glucose were estimated weekly. Cholesterol, SOD and CAT were estimated in the blood serum on 21 days of the investigation period. Oral administration of EAPR (500?mg/kg) significant rises in the body weight, decrease in the blood glucose and total cholesterol and restore function of SOD and CAT enzymes (P?

SUBMITTER: Abhimanyu KK

PROVIDER: S-EPMC5999010 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature

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Data on investigation of hypoglycemic, anti-cholesteremic, in vivo antioxidant and pancreatic beta cell protective effect of <i>Putranjiva roxburghii</i> Wall bark in streptozotocin-induced diabetic rats.

Abhimanyu Kedar Kalyani KK Ravindra Chaudhari Sanjay CS Avanapu Rao Srinivasa RS

Data in brief 20180502

The data existing in this article are associated to the antidiabetic activity of ethyl acetate extract of <i>Putranjiva roxburghii</i> Wall barks (EAPR) in streptozotocin (STZ) induced diabetic rats at a dose of 250 & 500 mg/kg by oral route for 21 days. The phytochemical screening of the extract was carried out by gas chromatography and mass spectrometry. Diabetes was induced by streptozotocin (50 mg/kg; i.p), EAPR (250 & 500 mg/kg; b.wt) and standard Insulin (6 IU/animal; subcutaneous; o.i.d) ...[more]

PMID: 29904686

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Project description:OBJECTIVE:The objective of the present study was to evaluate the effect of umbelliferon-?-D-glucopyranosyl-(2I???1II)-?-D-glucopyranoside (UFD) from Aegle marmelos Corr. on serum glucose, lipid profile and free radical scavenging activity in normal and STZ (streptozotocin) induced diabetic rats. MATERIALS AND METHODS:Diabetes was induced by single interperitoneal injecting of streptozotocin (60 mg/kg, i.p.) in the rats. All the rats were divided into following groups; I - nondiabeteic, II - nondiabetic?+?UFD (40 mg/kg, p.o.), III - diabetic control, IV - UFD (10 mg/kg, p.o.), V - UFD (20 mg/kg, p.o.), VI - UFD (40 mg/kg) and VII - glibenclamide (10 mg/kg, p.o.). Serum glucose level and body weight were determined periodically. Biochemical parameter, antioxidant enzyme and histopathology study were performed on the day 28. Oral glucose tolerance test study was performed to identify the glucose utilization capacity. RESULTS:All the doses of UFD and glibenclamide decrease the level of serum glucose, glycated hemoglobin, glucose-6-phosphatase, fructose-1-6-biphosphate and increased the level of plasma insulin, hexokinase. The UFD doses also showed effects on antioxidant enzymes viz. superoxide dismutase, catalase and glutathione peroxidase which were significantly increased and the level of malonaldehyde was markedly decreased. Histologically study, focal necrosis, deposition of fats, increased the size of the intercalated disc were observed in the diabetic rat liver, kidney, heart and pancreas but was less obvious in treated groups. The mechanism of action of the UFD emerges to be due to increase the activity of antioxidant enzyme and secretion of pancreatic insulin. CONCLUSION:Reduction in the FBG (fasting blood glucose), glycated hemoglobin, glucose-6-phosphatase, fructose-1-6-biphosphate, superoxide dismutase, catalase, glutathione peroxides, cholesterol, triglyceride, LDL, VLDL levels and improvement in the level of the plasma insulin, hexokinase, HDL was observed by the UFD treated rats. The result indicates that UFD has anti-diabetic activity along with anti hyperlipidemic and antioxidant efficacy and provides a scientific rationale to be used as an Anti-diabetic agent.

Dataset Information

Data on investigation of hypoglycemic, anti-cholesteremic, in vivo antioxidant and pancreatic beta cell protective effect of Putranjiva roxburghii Wall bark in streptozotocin-induced diabetic rats.

Publications

Data on investigation of hypoglycemic, anti-cholesteremic, in vivo antioxidant and pancreatic beta cell protective effect of <i>Putranjiva roxburghii</i> Wall bark in streptozotocin-induced diabetic rats.

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