Ontology highlight
ABSTRACT:
SUBMITTER: O'Driscoll NH
PROVIDER: S-EPMC6004271 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
O'Driscoll Noëlle H NH Cushnie T P Tim TPT Matthews Kerr H KH Lamb Andrew J AJ
Archives of microbiology 20180208 5
Whilst colistin (polymyxin E) represents the last mainstream treatment option for multidrug-resistant Gram-negative pathogens, details of its mechanism of action remain to be fully resolved. In this study, the effects of sub-inhibitory, inhibitory-bactericidal, and supra-bactericidal levels of colistin on the membrane integrity and morphology of Escherichia coli and Pseudomonas aeruginosa were investigated using potassium loss, flow cytometry, and scanning electron microscopy (SEM). Supra-bacter ...[more]