Ontology highlight
ABSTRACT:
SUBMITTER: Brocks D
PROVIDER: S-EPMC6005702 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Brocks David D Schmidt Christopher R CR Daskalakis Michael M Jang Hyo Sik HS Shah Nakul M NM Li Daofeng D Li Jing J Zhang Bo B Hou Yiran Y Laudato Sara S Lipka Daniel B DB Schott Johanna J Bierhoff Holger H Assenov Yassen Y Helf Monika M Ressnerova Alzbeta A Islam Md Saiful MS Lindroth Anders M AM Haas Simon S Essers Marieke M Imbusch Charles D CD Brors Benedikt B Oehme Ina I Witt Olaf O Lübbert Michael M Mallm Jan-Philipp JP Rippe Karsten K Will Rainer R Weichenhan Dieter D Stoecklin Georg G Gerhäuser Clarissa C Oakes Christopher C CC Wang Ting T Plass Christoph C
Nature genetics 20170612 7
Several mechanisms of action have been proposed for DNA methyltransferase and histone deacetylase inhibitors (DNMTi and HDACi), primarily based on candidate-gene approaches. However, less is known about their genome-wide transcriptional and epigenomic consequences. By mapping global transcription start site (TSS) and chromatin dynamics, we observed the cryptic transcription of thousands of treatment-induced non-annotated TSSs (TINATs) following DNMTi and HDACi treatment. The resulting transcript ...[more]