Ontology highlight
ABSTRACT:
SUBMITTER: Yamaguchi H
PROVIDER: S-EPMC6008050 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Yamaguchi Hiroshi H Oda Toshiyuki T Kikkawa Masahide M Takeda Hiroyuki H
eLife 20180509
Construction of motile cilia/flagella requires cytoplasmic preassembly of axonemal dyneins before transport into cilia. Axonemal dyneins have various subtypes, but the roles of each dynein subtype and their assembly processes remain elusive in vertebrates. The PIH protein family, consisting of four members, has been implicated in the assembly of different dynein subtypes, although evidence for this idea is sparse. Here, we established zebrafish mutants of all four PIH-protein genes: <i>pih1d1</i ...[more]