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Identification of five novel genetic loci related to facial morphology by genome-wide association studies.

ABSTRACT: BACKGROUND:Face morphology is strongly determined by genetic factors. However, only a small number of genes related to face morphology have been identified to date. Here, we performed a two-stage genome-wide association study (GWAS) of 85 face morphological traits in 7569 Koreans (5643 in the discovery set and 1926 in the replication set). RESULTS:In this study, we analyzed 85 facial traits, including facial angles. After discovery GWAS, 128 single nucleotide polymorphisms (SNPs) showing an association of P?

SUBMITTER: Cha S 

PROVIDER: S-EPMC6008943 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature

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Identification of five novel genetic loci related to facial morphology by genome-wide association studies.

Cha Seongwon S   Lim Ji Eun JE   Park Ah Yeon AY   Do Jun-Hyeong JH   Lee Si Woo SW   Shin Chol C   Cho Nam Han NH   Kang Ji-One JO   Nam Jeong Min JM   Kim Jong-Sik JS   Woo Kwang-Man KM   Lee Seung-Hwan SH   Kim Jong Yeol JY   Oh Bermseok B  

BMC genomics 20180619 1

<h4>Background</h4>Face morphology is strongly determined by genetic factors. However, only a small number of genes related to face morphology have been identified to date. Here, we performed a two-stage genome-wide association study (GWAS) of 85 face morphological traits in 7569 Koreans (5643 in the discovery set and 1926 in the replication set).<h4>Results</h4>In this study, we analyzed 85 facial traits, including facial angles. After discovery GWAS, 128 single nucleotide polymorphisms (SNPs)  ...[more]

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