Identification of five novel genetic loci related to facial morphology by genome-wide association studies.
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ABSTRACT:
SUBMITTER: Cha S
PROVIDER: S-EPMC6008943 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Publications
Identification of five novel genetic loci related to facial morphology by genome-wide association studies.
Cha Seongwon S Lim Ji Eun JE Park Ah Yeon AY Do Jun-Hyeong JH Lee Si Woo SW Shin Chol C Cho Nam Han NH Kang Ji-One JO Nam Jeong Min JM Kim Jong-Sik JS Woo Kwang-Man KM Lee Seung-Hwan SH Kim Jong Yeol JY Oh Bermseok B
BMC genomics 20180619 1
<h4>Background</h4>Face morphology is strongly determined by genetic factors. However, only a small number of genes related to face morphology have been identified to date. Here, we performed a two-stage genome-wide association study (GWAS) of 85 face morphological traits in 7569 Koreans (5643 in the discovery set and 1926 in the replication set).<h4>Results</h4>In this study, we analyzed 85 facial traits, including facial angles. After discovery GWAS, 128 single nucleotide polymorphisms (SNPs) ...[more]
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