Ontology highlight
ABSTRACT:
SUBMITTER: Gerard B
PROVIDER: S-EPMC3752688 | biostudies-literature | 2013 Jun
REPOSITORIES: biostudies-literature
Gerard Baudouin B Lee Maurice D MD Dandapani Sivaraman S Duvall Jeremy R JR Fitzgerald Mark E ME Kesavan Sarathy S Lowe Jason T JT Marié Jean-Charles JC Pandya Bhaumik A BA Suh Byung-Chul BC O'Shea Morgan Welzel MW Dombrowski Michael M Hamann Diane D Lemercier Berenice B Murillo Tiffanie T Akella Lakshmi B LB Foley Michael A MA Marcaurelle Lisa A LA
The Journal of organic chemistry 20130521 11
A diversity-oriented synthesis (DOS) strategy was developed for the synthesis of stereochemically diverse fused-ring systems containing a pyran moiety. Each scaffold contains an amine and methyl ester for further diversification via amine capping and amide coupling. Scaffold diversity was evaluated in comparison to previously prepared scaffolds by a shape-based principal moments of inertia (PMI) analysis. ...[more]