Ontology highlight
ABSTRACT:
SUBMITTER: Gramolelli S
PROVIDER: S-EPMC6015061 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Gramolelli Silvia S Cheng Jianpin J Martinez-Corral Ines I Vähä-Koskela Markus M Elbasani Endrit E Kaivanto Elisa E Rantanen Ville V Tuohinto Krista K Hautaniemi Sampsa S Bower Mark M Haglund Caj C Alitalo Kari K Mäkinen Taija T Petrova Tatiana V TV Lehti Kaisa K Ojala Päivi M PM
Scientific reports 20180622 1
The transcription factor PROX1 is essential for development and cell fate specification. Its function in cancer is context-dependent since PROX1 has been shown to play both oncogenic and tumour suppressive roles. Here, we show that PROX1 suppresses the transcription of MMP14, a metalloprotease involved in angiogenesis and cancer invasion, by binding and suppressing the activity of MMP14 promoter. Prox1 deletion in murine dermal lymphatic vessels in vivo and in human LECs increased MMP14 expressi ...[more]