Ontology highlight
ABSTRACT:
SUBMITTER: Gauvrit S
PROVIDER: S-EPMC6045644 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Gauvrit Sébastien S Villasenor Alethia A Strilic Boris B Kitchen Philip P Collins Michelle M MM Marín-Juez Rubén R Guenther Stefan S Maischein Hans-Martin HM Fukuda Nana N Canham Maurice A MA Brickman Joshua M JM Bogue Clifford W CW Jayaraman Padma-Sheela PS Stainier Didier Y R DYR
Nature communications 20180713 1
Formation of the lymphatic system requires the coordinated expression of several key regulators: vascular endothelial growth factor C (VEGFC), its receptor FLT4, and a key transcriptional effector, PROX1. Yet, how expression of these signaling components is regulated remains poorly understood. Here, using a combination of genetic and molecular approaches, we identify the transcription factor hematopoietically expressed homeobox (HHEX) as an upstream regulator of VEGFC, FLT4, and PROX1 during ang ...[more]