Ontology highlight
ABSTRACT:
SUBMITTER: Lohr H
PROVIDER: S-EPMC6015746 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Löhr Heiko H Hess Simon S Pereira Mafalda M A MMA Reinoß Philip P Leibold Sandra S Schenkel Christel C Wunderlich Claudia M CM Kloppenburg Peter P Brüning Jens C JC Hammerschmidt Matthias M
Cell reports 20180501 6
Anorexigenic pro-opiomelanocortin (Pomc)/alpha-melanocyte stimulating hormone (αMSH) neurons of the hypothalamic melanocortin system function as key regulators of energy homeostasis, also controlling somatic growth across different species. However, the mechanisms of melanocortin-dependent growth control still remain ill-defined. Here, we reveal a thus-far-unrecognized structural and functional connection between Pomc neurons and the somatotropic hypothalamo-pituitary axis. Excessive feeding of ...[more]