Ontology highlight
ABSTRACT:
SUBMITTER: Hitchcock AL
PROVIDER: S-EPMC60169 | biostudies-literature | 2001 Oct
REPOSITORIES: biostudies-literature
Hitchcock A L AL Krebber H H Frietze S S Lin A A Latterich M M Silver P A PA
Molecular biology of the cell 20011001 10
Proteolytic activation of membrane-bound transcription factors has emerged as an important mechanism for the regulation of gene expression. Two membrane-bound transcription factors regulated in this manner are the Saccharomyces cerevisiae proteins Mga2p and Spt23p, which direct transcription of the Delta9-fatty acid desaturase gene OLE1. We now show that a membrane-associated complex containing the highly conserved Npl4p, Ufd1p, and Cdc48p proteins mediates the proteasome-regulated cleavage of M ...[more]